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ABSTRACT




Mucositis oral en niños con cáncer y su relación con limitación de actividades

doi: 10.24875/j.gamo.M18000137

Full Article in PDF (Spanish)


VOLUME 17 - NUMBER 2 / Abril - Junio (Original Article)


Miguel Ángel Palomo-Colli, Departamento de Oncología, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Diana Carolina Soltero-Becerril, Departamento de Pediatría Médica. Hospital Infantil de México Federico Gómez, Ciudad de México, México
Luis Enrique Juárez Villegas, Departamento de Oncología, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Carlo Cicero-Oneto, Departamento de Oncología, Hospital Infantil de México Federico Gómez, Ciudad de México, México
José Félix Gaytán-Morales, Departamento de Oncología, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Iván Castorena-Villa, Departamento de Oncología, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Mónica Mier-Cabrera, Departamento de Oncología, Hospital Regional de Alta especialidad de Ixtapaluca, Ixtapaluca, México



Introduction: Oral mucositis (OM) is a common chemo and radiotherapy adverse effect in oncological pediatric patients, oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment. Methods: We included 420 children and monitored them for 2 weeks after the initiation of chemotherapy between June 2012 and June 2016. Subjects were asked to use a daily diary to complete the related questions of the OM Daily Questionnaire from the start of chemotherapy to day 14. Results: Overall, 73% (n = 307) of paediatric patients developed OM. Most cases were Grade 2 and 3. Of these, 12% (n = 32) were Grade 1, and 49% (n = 205) Grade 2. The mean time to onset of OM was 4.5 (standard deviation [SD]: 2.5; range: 2-9; 95% confidence interval [CI]: 3.8-5.3) days after the start of chemotherapy, with a mean duration of 6.5 (SD: 4; range: 2-13; 95% CI: 5.2-9.4) days and with the peak at day 7.1 (SD: 2.8; range: 4-11; 95% CI: 6.8-8.4). Conclusions: OM is associated with negative effects on clinical outcomes.


Keywords: Mucositis. Cancer. Chemotherapy. Quality of life. Children.