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ABSTRACT




La ketamina, una alternativa en el tratamiento anestésico del paciente oncológico

doi: 10.24875/j.gamo.18000077

Full Article in PDF (Spanish)


VOLUME 17 - NUMBER 2 / Abril - Junio (Review Article)


Horacio Vázquez-Morales, Departamento de Anestesiología y Terapia Intensiva, Instituto Nacional de Cancerología, Ciudad de México, México
Luis Felipe Cuellar-Guzmán, Departamento de Anestesiología y profesor titular del Curso de Alta Especialidad en Anestesia Oncológica, Instituto Nacional de Cancerología, Ciudad de México, México
Daniela Arévalo-Villa, Departamento de Anestesiología y Terapia Intensiva, Instituto Nacional de Cancerología, Ciudad de México, México



Cancer is the second cause of death in the world and the third in Mexico. The vast majority of deaths are due to metastatic disease secondary to the spread of tumor cells that occurs due to the loss of homeostasis of the body that undergoes a surgical procedure, producing an inflammatory process which is one of the most important factors in this imbalance and causing headline damage and organic dysfunction. The objective of this review is to show the positive effects of ketamine in the regulation of inflammation and pain control through N-methyl-d-aspartate receptors at different levels of action, such as in the recruitment of inflammatory cells, cytokine production and regulation of modulators of inflammation. These antiproinflammatory effects give ketamine immunomodulatory properties that may be useful in cancer patients undergoing surgery


Keywords: Ketamine. Cancer. Pain. Inflammation. Citokine.