VOLUME 21 - NUMBER 2 / April - June (Original article / Artículo original)
Jesús A. Lara-Reyes, Brain Research, Universidad Veracruzana, Xalapa, Ver., Mexico
Zuleima H. Castillo-García, Faculty of Bioanalysis, Universidad Veracruzana, Xalapa, Ver., Mexico
Gonzalo E. Aranda-Abreu, Brain Research Institute, Universidad Veracruzana, Xalapa, Ver., Mexico
Deissy Herrera-Covarrubias, Brain Research Institute, Universidad Veracruzana, Xalapa, Ver., Mexico
Clara L. Sampieri-Ramírez, Public Health Institute, Universidad Veracruzana, Xalapa, Ver., Mexico
Arnoldo Aquino-Gálvez, Molecular Biology Laboratory, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
Jorge M. Suárez-Medellín, Brain Research Institute, Universidad Veracruzana, Xalapa, Ver., Mexico
Ma. Elena Hernández-Aguilar, Brain Research Institute, Universidad Veracruzana, Xalapa, Ver., Mexico
Fausto Rojas-Durán, Brain Research Institute, Universidad Veracruzana, Xalapa, Ver., Mexico
Objective: To evaluate the effect of prolactin (PRL) on the migration of MCF-7 breast cancer cells and the expression of E-cadherin. Methods: We used the wound healing assays to evaluate the migration of MCF-7 cells and the Western blot technique to evaluate the expression of E-cadherin. Results: The results show that PRL produced an increase in the migration of MCF-7 cells without inducing a reduction in the expression of E-cadherin. Conclusions: Prolactin significantly increased the migration of MCF-7 breast cancer cell line without inducing an epithelial-mesenchymal transition (EMT), which could be related to a collective type of migration.
Keywords: Prolactin. MCF-7 cells. Epithelial-mesenchymal transition. Cell migration assays. Cell movement. Breast neoplasms.
