VOLUME 21 - NUMBER 3 / July - September (Original articles / Artículos originales)
Andrea G. Rodríguez-López, Physical-Mathematical Department, Universidad Autónoma de San Luis Potosí, S.L.P., Mexico
Mónica L. Córdova-Serrano, Faculty of Chemical Sciences, Universidad Autónoma de San Luis Potosí, S.L.P., Mexico
Ana L. González-Bolaños, Faculty of Chemical Sciences, Universidad Autónoma de San Luis Potosí, S.L.P., Mexico
Karen B. Téllez-Blanco, Faculty of Chemical Sciences, Universidad Autónoma de San Luis Potosí, S.L.P., Mexico
Laura S. Marín-Jaureguí, Division of Molecular and Translational Medicine, Research Center of Health Science and Biomedicine, Universidad Autónoma de San Luis Potosí, S.L.P., Mexico
Ma. José Santoyo-Treviño, Coordination for Innovation and Application of Science and Technology. Universidad Autónoma de San Luis Potosí, S.L.P., Mexico
Aida C. Hernández-Arteaga, Coordination for Innovation and Application of Science and Technology. Universidad Autónoma de San Luis Potosí, S.L.P., Mexico
Objective: To evaluate the relationship between the use of HC and the concentration of Sialic acid (CSA) detected in the saliva of 120 women from San Luís Potosí, Mexico. Methods: Three groups were evaluated: control group, HC intake shorter than 4 years, and HC intake longer than 4 years. A questionnaire was applied, anthropometric measures were taken, and collection of saliva samples was carried out. The samples were analyzed with Raman-SERS, for which silver nanoparticles were synthesized, and the measurement of SA was held. Results: The concentrations were divided into three SA groups: normal (≤ 4 mg/dL), risk (> 4-7 mg/dL), and altered (> 7 mg/dL). The maximum CSA was detected, which was 9.2 mg/dL. All the volunteers who used the intrauterine system (IUS) and most of the ones who used the pills and subdermal implant (SI) presented risk and altered concentrations. Conclusions: That there is an association between the HC and the CSA, presenting a higher concentration, those volunteers who used IUS, contraceptive pills, and SI.
Keywords: Breast cancer. Hormonal contraceptive. Sialic acid. SERS. Raman spectroscopy.
