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ABSTRACT

New insights about organoids as model of study for breast cancer research

doi: 10.24875/j.gamo.22000110

Full Article in PDF (English)



VOLUME 21 - NUMBER 4 / October-December (Review article / Artículo de revisión)


Ignacio U. Macías-Paz, Dr. Alberto Romo Caballero´s School of Medicine, Research Division, Universidad Autónoma de Tamaulipas, Tampico, Tamps., Mexico
Alejandro Rivera-Arenas, Dr. Alberto Romo Caballero´s School of Medicine, Research Division, Universidad Autónoma de Tamaulipas, Tampico, Tamps., Mexico
Elizabeth Reyna-Beltrán, Dr. Alberto Romo Caballero´s School of Medicine, Research Division, Universidad Autónoma de Tamaulipas, Tampico, Tamps., Mexico
Alejandra Tavera-Tapia, Dr. Alberto Romo Caballero´s School of Medicine, Research Division, Universidad Autónoma de Tamaulipas, Tampico, Tamps., Mexico



Although the current advances in breast cancer (BC) research, it is still one of the leading causes of death from neoplastic diseases in women and causes millions of new cases worldwide. It has become evident that traditional methods used for BC research have serious limitations. We have reviewed the most recent findings in the application of Breast Cancer Organoids (BCOs) to explore extremely rare BC forms, BC hallmarks, biobanks, and interaction with the microenvironment. Moreover, we explored the importance of its applicability in clinical trials, drug screening, and personalized medicine.


Keywords: Organoids. Breast cancer. Clinical trials. Personalized medicine.