VOLUME 16 - NUMBER 5 / September-October (Original article / Artículo original)
Carlos Alfonso Duarte, Coordinador del Grupo Cirugía Oncológica, Instituto Nacional de Cancerología, Bogotá, Colombia
Andrés Felipe Rojas, Fellow del Grupo Cirugía Oncológica, Instituto Nacional de Cancerología, Bogotá, Colombia
Javier Ángel, Grupo de Mama y Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá, Colombia
Sandra Díaz, Grupo de Mama y Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá, Colombia
Óscar García, Grupo de Mama y Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá, Colombia
Mauricio García, Grupo de Mama y Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá, Colombia
Carlos Lehman, Grupo de Mama y Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá, Colombia
Ricardo Sánchez, Grupo Investigación Clínica, Instituto Nacional de Cancerología, Bogotá, Colombia
Objective: Describe the experience in implementing the technique of isolated limb perfusion with the use of melphalan in patients with soft tissue sarcoma (STS), between 2007 and 2012. Methodology: A case series of patients diagnosed with STS and standing tumors and/or cutaneous annex carried by isolated limb perfusion Service Breast and Soft Tissues in the Instituto Nacional de Salud in Bogotá-Colombia from 2007 to 2012. Descriptive analysis of information was made. Qualitative variables were presented in frequencies and proportions and quantitative variables median and interquartile ranges (IQR) was made due to non-normal distribution. Results: They were included in the study 52 patients with a median of 53 (IQR = 37-66) years, treatment response according to RECIST scale was partial in 45.83% and 39.5% progression. The
definitive surgical treatment was performed in 83.3% (40). The percentage of overall saving was 45%. Secondary mortality was at present in 21.57% (11) and the free disease-free survival was 50.98% (26). Conclusions: Isolated limb perfusion is a successful alternative to amputation, but in our series a low saving rate was found comparing other centers where combination therapy is used with tumor necrosis factor. It is considered advisable to carry out prospective studies with robust methodologies where this combination is used to evaluate the response rate in the Colombian population and better respond to patients with this disease.
Keywords: Soft tissue sarcoma. Isolated limb perfusion. Melphalan. Therapeutic response. Mortality. Limb salvage.
