Ricardo Santana-Hernández, Department of Oncosurgery, Hospital Regional León, ISSSTE, León, Gto., Mexico
Julia B. Monroy-Romero, Department of Surgery. Hospital Regional León, ISSSTE, León, Gto., Mexico
Juan M. Guillén-Montiel, Department of Surgery. Hospital Regional León, ISSSTE, León, Gto., Mexico
Raúl A. Carpinteyro-Espinoza, Department of Surgery. Hospital Regional León, ISSSTE, León, Gto., Mexico
Julio C. Ruíz-de los Santos, Department of Surgery. Hospital Regional León, ISSSTE, León, Gto., Mexico
Luis Á. Ponce-Rea, Department of Surgery. Hospital Regional León, ISSSTE, León, Gto., Mexico


Paragangliomas correspond to tumors of neuroendocrine origin of chromaffin cells in the paraganglia of the sympathetic or parasympathetic nervous system, particularly those located in the larynx being extremely rare, contributing to < 0.6% of laryngeal tumors. Most are sporadic, although 40% may have a familial occurrence. Symptoms depend on size, generally including dysphonia, dysphagia, or a foreign body sensation. The diagnosis is established by laryngoscopy and CT, observing soft-tissue masses with well-defined contours, coupled with histological confirmation by the presence of stem cells in a “Zell Balen” configuration, and immunohistochemistry with chromogranin and S100 protein.



Keywords: Paraganglioma. Neoplasms. Chromaffin cells.