Judith del R. Bermudez-Ruiz, General Surgery, Hospital Regional ISSSTE León, Universidad de Guanajuato, León, Gto., Mexico
Raúl Guillén-González, General Surgery, Hospital Aranda de La Parra, León, Gto., Mexico
Lucero G. Vázquez-Sánchez, General Surgery, Hospital Regional ISSSTE León, Universidad de Guanajuato, León, Gto., Mexico
Alondra G. Mercado-Mendiola, General Surgery, Hospital Regional ISSSTE León, Universidad de Guanajuato, León, Gto., Mexico
Ana S. González-Izaguirre, General Surgery, Hospital Regional ISSSTE León, Universidad de Guanajuato, León, Gto., Mexico
Marisol Ramos-Portales, General Surgery, Hospital Regional ISSSTE León, Universidad de Guanajuato, León, Gto., Mexico
Victor A. Vázquez-Sánchez, Imaging and Therapeutic Diagnosis, Hospital Regional de Alta Especialidad del Bajío, León, Gto., Mexico
Zazil Botello-Hernandez, General Surgery, Hospital Regional ISSSTE León, Universidad de Guanajuato, León, Gto., Mexico

Undifferentiated osteoclast-like giant cell pancreatic carcinoma (UC-OGC) is a rare pancreatic carcinoma that is composed of osteoclast-like giant cells among other cells and is hardly described in the literature due to its infrequent presentation. We report a 63-year-old Mexican woman who presented with undifferentiated pancreatic carcinoma with osteoclast-like cells mimicking a cystic tumor, with a successful surgical treatment with a follow-up of 3 years without deterioration. We present this case to add to the existing literature on UC-OGC of the pancreas since it is an extremely rare pathology with little information about its treatment.